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From QuB

QuB is a software package for Markov analysis of single-molecule kinetics, especially ion channel records.

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With QuB's user-friendly graphical interfaces, you can simulate single-channel currents for any model calculate rate constants and voltage-dependence without fitting histograms detect current transitions in the presence of noise filter data, correct baseline, and select subintervals test all possible model topologies fit data to any function or system of ODEs (more...)

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Documentation

• Table of Contents -- the online manual
• QuB Manual 2004 (.doc) (outdated)
• QuB Programming Manual
• the Help menu in QuB

New and featured pages

• Papers about QuB
• Research using QuB -- add your citation or website here
• How to satisfy cycle (im)balance
• How to import data
• Model Theory
• Choosing a Scaling value
• QFC -- QuB Fitting Curves -- a new, free program for nonlinear least-squares regression
• Example of how to use the file list: Global Fitting Tutorial

• ModelDB (external site) -- database of models for computational neuroscience
• Significance tests harm progress in forecasting (pdf)
• Linking Exponential Components to Kinetic States in Markov Models for Single-Channel Gating - Shelley and Magleby

Answers to your emails

• How to set Q (Voltage)
• Multichannel Patches
• Custom histograms
• How to choose Dead Time
• How to plot cluster number vs class occupancy
• Why don't Idealization stats match MIL time constants?
• Can I analyze two different channels in a patch?
• Help! QuB won't open a data file
• (more...)

Send questions to "qub @ www.qub.buffalo.edu"