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QuB is a software package for Markov analysis of single-molecule kinetics, especially ion channel records.

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With QuB's user-friendly graphical interfaces, you can simulate single-channel currents for any model calculate rate constants and voltage-dependence without fitting histograms detect current transitions in the presence of noise filter data, correct baseline, and select subintervals test all possible model topologies fit data to any function or system of ODEs (more...) New in QuB 1.5: Opens ABF and ABF2 files Solves for rate constants, stimulus dependence, unitary conductance and variance in multi-channel patches Extracts data from several files into one; can average congruent selections/lists from different files Windows Vista compatible

Download QuB  Read more...

Download Fitness  Read more...

Download QUBIO  Read more...

Documentation

• Table of Contents -- the online manual
• *new* QuB Forums
• QuB Manual 2004 (.doc) (outdated)
• QuB Programming Manual
• the Help menu in QuB

• Fitness manual

New and featured pages

• Papers about QuB
• Research using QuB -- please send citations when you're published
• How to satisfy cycle (im)balance
• How to import data
• Model Theory
• Choosing a Scaling value
• Fitness -- QuB curve fitting -- a new, free program for nonlinear least-squares regression and differential modeling
• Example using Fitness with differential equations

• ModelDB (external site) -- database of models for computational neuroscience
• Significance tests harm progress in forecasting (pdf)
• Linking Exponential Components to Kinetic States in Markov Models for Single-Channel Gating - Shelley and Magleby

• Macroscopic Analysis -- A tutorial
• Dynamic Clamp -- Modeling ion channels in real time

Answers to your emails

• How to export data for Clampfit
• How to set Q (Voltage)
• Multichannel Patches
• Custom histograms
• How to choose Dead Time
• How to plot cluster number vs class occupancy
• Why don't Idealization stats match MIL time constants?
• Can I analyze two different channels in a patch?
• Help! QuB won't open a data file
• How can I discriminate between models with the same LL?
• (more...)

Post questions in the forum, or send them to "qub @ www.qub.buffalo.edu"