Research using QuB

From QuB

Prev: Papers about QuB	Outline	Next: Other Software

If you have published a paper using QuB, or you have a lab web site describing ongoing research using QuB, please edit this page. Add new entries at the top of the relevant section.

PubMed search

Papers using QuB

Taufiq-Ur-Rahman, Skupin A, Falcke M, Taylor CW (2009)
Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.
Nature 458:655-659

Liu, J., Vaithianathan, T., Manivannan, K. Parrill, A., Dopico, M.,
Ethanol modulates BKca channels by acting as an adjuvant of calcium.
Molecular Pharmacology Fast Forward. Published on June 13, 2008 as doi:10.1124/mol.108.048694

Bittner, K.C., Hanck, D.A.,
The Relationship between Single-Channel and Whole-Cell Conductance in the T-type Ca2+ Channel Cav3.1.
Biophys J. 95:931-941

Farbman, M.E., Gershenson, A., Licht, S.,
Single-Molecule Analysis of Nucleotide-Dependent Substrate Binding by the Protein Unfoldase ClpA.
Journal of the American Chemical Society, in press (Communication).

Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S. (2007)
Mechanisms of neurosteroid interactions with GABA(A) receptors.
Pharmacol Ther. (Epub ahead of print)

Tan, W., Loke, Y.H., Stein, C.A., Miller, P., Colombini, M. (2007)
Phosphorothioate Oligonucleotides Block the VDAC Channel.
Biophys J. 93(4):1184-91

Rosen A, Bali M, Horenstein J, Akabas MH. (2007)
Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment.
Biophys J. 92(9):3130-9

Cadugan, D.J., Auerbach, A. (2007)
Conformational dynamics of the alphaM3 transmembrane helix during acetylcholine receptor channel gating.
Biophys J. 93(3): 859-65.

Corradi, J., Spitzmaul, G., De Rosa, M.J., Costabel, M., and Bouzat, C. (2007)
Role of pairwise interactions between M1 and M2 domains of the nicotinic receptor in channel gating.
Biophysical Journal 92: 76-86

Li Y, Berke I, Chen L, Jiang Y. (2007)
Gating and inward rectifying properties of the MthK K+ channel with and without the gating ring.
J Gen Physiol. 129(2), 109-20

Li W, Gao SB, Lv CX, Wu Y, Guo ZH, Ding JP, Xu T. (2007)
Characterization of voltage-and Ca(2+)-activated K(+) channels in rat dorsal root ganglion neurons.
J Cell Physiol. 212(2), 348-57.

Li P, Bracamontes J, Katona BW, Covey DF, Steinbach JH, Akk G. (2007)
Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor.
Mol Pharmacol. 71(6), 1582-90.

Mukhtasimova, N., Sine, S.M. (2007)
An intersubunit trigger of channel gating in the muscle nicotinic receptor.
J Neurosci 27(15): 4110-9

Munro, J.B., Altman, R.B., O'Connor, N., and Blanchard, S.C. (2007)
Identification of two distinct hybrid state intermediates on the ribosome.
Molecular Cell 25: 505-517

Purohit, P., Mitra, A., Auerbach, A. (2007)
A stepwise mechanism for acetylcholine receptor gating.
Nature 446(7138): 930-3.

Eisenman LN, Shu HJ, Akk G, Wang C, Manion BD, Kress GJ, Evers AS, Steinbach JH, Covey DF, Zorumski CF, Mennerick S. (2007)
Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.
Nat Neurosci. 10(4), 523-30

Akk G, Li P, Manion BD, Evers AS, Steinbach JH. (2007)
Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor.
Mol Pharmacol. 71(2), 461-72

Dravid, S.M., Erreger, K., Yuan, H., Nicholson, K., Le, P., Lyuboslavsky, P., Almonte, A., Murray, E., Mosely, C., Barber, J., French, A., Balster, R., Murray, T.F, Traynelis, S.F. (2007)
Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block.
J Physiol 581: 107-128.

Lagrange, A.H., Botzolakis, E.J., Macdonald, R.L. (2007)
Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA
J Physiol 578 (Pt 3): 655-676

Michaelevski I, Korngreen A, Lotan I. (2007)
Interaction of syntaxin with a single Kv1.1 channel: a possible mechanism for modulating neuronal excitability.
Pflugers Arch. 454(3):477-94

Danelon, C., Grandl, J., Hovius, R., Vogel, H. (2007)
Modulation of proton-induced current fluctuations in the human nicotinic acetylcholine receptor channel.
Biochim. Biophys. Acta 1768:76-89.

Grandl, J., Danelon, C., Hovius, R., Vogel, H. (2006)
Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors.
Eur. Biophys. J. 35:685-693.

Jones, B.L., Whiting, P.J., Henderson, L.P. (2006)
Mechanisms of anabolic androgenic steroid inhibition of mammalian varepsilon-subunit-containing GABAA receptors
J Physiol 573: 571-593

Ionescu, L., Cheung, K-H., Vais, H., Mak, D.D., White, C., Foskett, J.K. (2006)
Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quartal Ca2+release
J Physiol 573: 645-662

Campos De Oliveira, R.A., Barbosa, C.T.F., Consoni, L.H.A., Rodrigues, A.R.A., Varanda, W.A, Nogueira, R.A. (2006)
Long-term correlation in single calcium-activated potassium channel kinetics.
Physica A 364 (15 May 2006): 13-22

Bartos, M., Rayes, D., and Bouzat, C. (2006)
Molecular determinants of pyrantel selectivity in nicotinic receptors
Molecular Pharmacology 70: 1307-1318

Cai, Z., Taddei, A., Sheppard, D.N. (2006)
Differential sensitivity of the cystic fibrosis (CF)-associated mutants G551D and G1349D to potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.
J Biol Chem 281(4): 1970-7.

Lema, G.M., Auerbach, A. (2006)
Modes and models of GABA(A) receptor gating.
J Physiol. 572(1): 183-200.

Li P, Covey DF, Steinbach JH, Akk G. (2006)
Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors.
Mol Pharmacol. 69(6), 2015-26

Milescu, L.S., Yildiz, A., Selvin, P.R., Sachs, F. (2006)
Maximum Likelihood Estimation of Molecular Motor Kinetics from Staircase Dwell-Time Sequences.
Biophys J. 91(4): 1156-68.

Dellis O, Dedos SG, Tovey SC, Taufiq-Ur-Rahman , Dubel SJ, Taylor CW. (2006)
Ca2+ entry through plasma membrane IP3 receptors.
Science 313(5784):229-33

Ribalet B, John SA, Xie L-H, and Weiss JN. (2006)
ATP-sensitive K channels: regulation of bursting by the sulfonylurea receptor, PIP2 and regions of Kir6.2.
J Physiol. 571.2, 303-317.

Shen, X.M., Deymeer, F., Sine, S.M., Engel, A.G. (2006)
Slow-channel mutation in acetylcholine receptor aM4 domain and its efficient knockdown.
Annals of Neurology 60(1): 128-136.

Brown, A.L., Fernandez-Illescas, S.M., Liao, Z., and Goodman, M.B. (2006)
Gain-of-Function Mutations in the MEC-4 DEG/ENaC Sensory Mechanotransduction Channel Alter Gating and Drug Blockade,
J. Gen. Physiol. 129(2), 161-173

Zhang Z, Zhou Y, Ding JP, Xia XM, Lingle CJ. (2006)
A limited access compartment between the pore domain and cytosolic domain of the BK channel.
J Neurosci. 26(46), 11833-43.

Yao J, Li H, Gan GL, Wu Y, Ding JP. (2006)
Residue Phe266 in S5-S6 loop is not critical for Charybdotoxin binding to Ca2+-activated K+ (mSlo1) channels.
Acta Pharmacol Sin. 27(7), 945-9.

Elenes S, Ni Y, Cymes GD, Grosman C. (2006)
Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor,
J Gen Physiol. 128(5), 615-27

Purohit Y, Grosman C. (2006)
Estimating binding affinities of the nicotinic receptor for low-efficacy ligands using mixtures of agonists and two-dimensional concentration-response relationships,
J Gen Physiol. 127(6), 719-35

Purohit Y, Grosman C. (2006)
Block of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities,
J Gen Physiol. 127(6), 703-17

Popescu, G (2005)
Principles of N-methyl-D-aspartate receptor allosteric modulation.
Mol Pharmacol. 2005 Oct;68(4):1148-55.

Akk G, Shu HJ, Wang C, Steinbach JH, Zorumski CF, Covey DF, Mennerick S. (2005)
Neurosteroid access to the GABAA receptor.
J Neurosci. 25(50), 11605-13

Akk G, Steinbach JH. (2005)
Galantamine activates muscle-type nicotinic acetylcholine receptors without binding to the acetylcholine-binding site.
J Neurosci. 25(8), 1992-2001

Akk G, Milescu LS, Heckmann M. (2005)
Activation of heteroliganded mouse muscle nicotinic receptors.
J Physiol. 564(Pt 2), 359-76

Anishkin, A., Chiang, C.S., Sukharev, S. (2005)
Gain-of-function mutations reveal expanded intermediate states and a sequential action of two gates in MscL.
J Gen Physiol 125(2): 155-70.

Chakrapani, S., Auerbach, A. (2005)
A speed limit for conformational change of an allosteric membrane protein.
Proc Natl Acad Sci USA 102(1): 87-92.

Gao, L., Mi, X., Paajanen, V., Wang, K., Fan, Z. (2005)
Activation-coupled inactivation in the bacterial potassium channel KcsA.
Proc Natl Acad Sci USA 102(49): 17630-5.

Milescu LS, Akk G, Sachs F. (2005)
Maximum likelihood estimation of ion channel kinetics from macroscopic currents.
Biophys J. 88(4), 2494-515

Mitra, A., Tascione, R., Auerbach, A., Licht, S. (2005)
Plasticity of acetylcholine receptor gating motions via rate-energy relationships.
Biophys J. 89(5): 3071-8.

Mitra, A., Cymes, G.D., Auerbach, A. (2005)
Dynamics of the acetylcholine receptor pore at the gating transition state.
Proc Natl Acad Sci USA 102(42): 15069-74

Mukhtasimova, N., Free, C., Sine, S.M. (2005)
Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor.
J Gen Physiol. 126(1): 23-39.

D. Rayes, G. Spitzmaul, S. Sine and C. Bouzat (2005)
Single-channel kinetic analysis of chimeric a7-5HT3 receptors.
Molecular Pharmacology 68: 1475-83

Yang H, Zhang C, Zheng H, Xiong W, Zhou Z, Xu T, Ding JP. (2005)
A simulation study on the Ca2+-independent but voltage-dependent exocytosis and endocytosis in dorsal root ganglion neurons.
Eur Biophys J. 34(8), 1007-16.

Cymes GD, Ni Y, Grosman C. (2005)
Probing ion-channel pores one proton at a time.
Nature 438(7070), 975-80

Auerbach, A. (2005)
Gating of acetylcholine receptor channels: brownian motion across a broad transition state.
Proc Natl Acad Sci USA<i> 102(5): 1408-12.

Auerbach, A., Zhou, Y. (2005)
Gating reaction mechanisms for NMDA receptor channels.
<i>J Neurosci. 25(35): 7914-23.

Raisinghani, M., Pabbidi, R.M., Premkumar, L.S. (2005)
Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin
J Physiol 567: 771-786

Smith, S.S. and Gong, Q.H. (2005)
Neurosteroid administration and withdrawal alter GABAA receptor kinetics in CA1 hippocampus of female rats
J Physiol 564: 421-436

Erreger, K., Dravid, S.M., Banke, T.G., Wyllie, D.J.A, Traynelis, S.F. (2005)
Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles
J Physiol 563: 345-358

Erreger, K., Geballe, M.T., Dravid, S.M., Snyder, J.P., Wyllie, D.J.A,, Traynelis, S.F. (2005)
Mechanism of Partial Agonism at NMDA Receptors for a Conformationally Restricted Glutamate Analog.
J Neurosci. 25(34): 7858-7866

Rayes, D., De Rosa, M.J., Bartos M., and Bouzat C. (2004)
Molecular basis of the differential sensitivity of nematode and mammalian muscle to the anthelminitic agent levamisole.
J. Biological Chemistry 279: 36372-36381

Spitzmaul, G., Corradi, J. and Bouzat, C. (2004)
Mechanistic contributions of residues in the M1 transmembrane domain of the nicotinic receptor to channel gating.
Molecular Membrane Biology 21: 39-50

Craven, M., Sergeant, G. P., Hollywood, M. A., McHale, N. G., Thornbury, K. D. (2004)
Modulation of spontaneous Ca2+-activated Cl– currents in the rabbit corpus cavernosum by the nitric oxide–cGMP pathway
J Physiol 556: 495-506

Popescu, G, Robert A, Howe JR and Auerbach A, (2004)
Reaction mechanism determines the NMDA receptor response to repetitive stimulation
Nature 430(7001): 790-793

Lee, W.Y., Sine, S.M. (2004)
Invariant aspartic Acid in muscle nicotinic receptor contributes selectively to the kinetics of agonist binding.
J Gen Physiol. 124(5): 555-67.

Banderali U., Klein H., Garneau L., Simoes M., Parent L., Sauvé R. (2004)
New insights on the voltage dependence of the KCa3.1 block by internal TBA.
J. Gen. Physiol. 124:333-348

Vaithianathan T. et al 2004
Neural Cell Adhesion Molecule-associated Polysialic Acid Potentiates -Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Currents(Thirumalini Vaithianathan, Katja Matthias, Ben Bahr, Melitta Schachner, Vishnu Suppiramaniam, Alexander Dityatev, and Christian Steinhauser 2004)

Hollywood, M. A., Woolsey, S., Walsh, I. K., Keane, P. F., McHale, N. G., Thornbury, K. D. (2003)
T- and L-type Ca2+ currents in freshly dispersed smooth muscle cells from the human proximal urethra
J Physiol 550: 753-764

Duncan, R. K., Fuchs, P. A. (2003)
Variation in large-conductance, calcium-activated potassium channels from hair cells along the chicken basilar papilla
J Physiol 547: 357-371

Grosman C. (2003)
Free-energy landscapes of ion-channel gating are malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels.
Biochemistry 42(50), 14977-87.

Watanabe, I., Wang, H-G., Sutachan, J.J., Zhu, J., Recio-Pinto, E., Thornhill, W.B. (2003)
Glycosylation affects rat Kv1.1 potassium channel gating by a combined surface potential and cooperative subunit interaction mechanism
J Physiol 550: 51-66

Banke, T.G., Traynelis, S.F. (2003)
Activation of NR1/NR2B NMDA receptors.
Nature Neuroscience 6: 144-152.

Cai, Z., Scott-Ward, T.S., Sheppard, D.N. (2003)
Voltage-dependent gating of the cystic fibrosis transmembrane conductance regulator Cl- channel.
J Gen Physiol. 122(5): 605-20.

Chakrapani, S., Bailey, TD, Auerbach, A. (2003)
The role of loop 5 in acetylcholine receptor gating,
J. Gen. Physiol. 122(5), 521-39

Grosman, C. (2003)
Free-energy Landscapes of Ion-channel Gating Are Malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels.
Biochemistry 42(50): 14977-87.

Han, J., Kang, D., Kim, D. (2003)
Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate
J Physiol. 550: 693-706.

Popescu, G. and Auerbach, A. (2003)
Modal gating of NMDA receptors and the shape of their synaptic current
Nature Neuroscience May; 6(5):476-83

Cai, Z., Sheppard, D.N. (2002)
Phloxine B interacts with the cystic fibrosis transmembrane conductance regulator at multiple sites to modulate channel activity.
J Biol Chem. 277(22): 19546-53.

Cymes GD, Grosman C, Auerbach A. (2002)
Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis.
Biochemistry 41(17), 5548-55.

Wu, S-N, Chen, C-C, Li, H-F, Lo, Y-K, Chen, S-A, Chiang, H-T (2002)
Stimulation of the BKca channel in cultured smooth muscle cells of human trachea by magnolol

Premkumar, L.S., Agarwal, S., and Steffen, D. (2002)
Single-channel properties of native and cloned rat vanilloid receptors
J Physiol 545: 107-117

Ding, S., Sachs, F. (2002)
Evidence for non-independent gating of P2X2 receptors expressed in Xenopus oocytes.
BMC Neurosci. 2002 Nov 6; 3:17

Simoes M., Garneau L., Klein H., Banderali U., Hobeila F., Roux B., Parent L., Sauvé R. (2002)
Cysteine mutagenesis and computer modeling of the S6 region on an intermediate conductance IKCa channel.
J. Gen. Physiol. 120:99-116

Grosman, C., Auerbach, A. (2001)
The dissociation of acetylcholine from open nicotinic receptor channels.
Proc Natl Acad Sci USA<i> 98(24): 14102-7.

Gil, Z., Magleby, K.L., Silberberg, S.D. (2001)
Two-dimensional kinetic analysis suggests nonsequential gating of mechanosensitive channels in Xenopus oocytes.
<i>Biophys J. 81(4): 2082-99.

Zhu, Y., Auerbach, A. (2001)
Na(+) occupancy and Mg(2+) block of the n-methyl-d-aspartate receptor channel.
J Gen Physiol. 117(3): 275-86.

Kim, D., Pleumsamran, A. (2000)
Cytoplasmic unsaturated free fatty acids inhibit ATP-dependent gating of the G protein-gated K(+) channel.
J. Gen. Physiol. 115(3): 287-304

Grosman, C., Zhou, M., Auerbach, A. (2000)
Mapping the conformational wave of acetylcholine receptor channel gating.
Nature 403: 773-776.

Grosman, C., Auerbach, A. (2000)
Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants.
J Gen Physiol. 115(5): 621-35.

Grosman, C., Auerbach, A. (2000)
Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist.
J Gen Physiol. 115(5): 637-51.

Grosman, C., Salamone, F.N., Sine, S.M., Auerbach, A. (2000)
The extracellular linker of muscle acetylcholine receptor channels is a gating control element.
J Gen Physiol 116(3): 327-40.

Li, J., Lester, H.A. (1999)
Single-Channel Kinetics of the Rat Olfactory Cyclic Nucleotide-Gated Channel Expressed in Xenopus Oocytes

Ding, S., Sachs, F. (1999)
Single channel properties of P2X2 purinoceptors.
J Gen Physiol. 113(5): 695-720

Sukharev,S., Sigurdson,W., Kung,C. & Sachs,F. (1999)
Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL.
J Gen Physiol 113, 525-539

Kim, D., Bang, H. (1999)
Modulation of rat atrial G protein-coupled K+ channel function by phospholipids.
J Physiol. 517(1): 59-74.

Zhou, M., Engel, A.G., Auerbach, A. (1999)
Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes.
Proc Natl Acad Sci USA 96(18): 10466-71.

Prince, R. J., Sine, S. M. (1998)
Epibatidine Activates Muscle Acetylcholine Receptors with Unique Site Selectivity.
Biophys J 75: 1817-1827
View this paper at the Biophysical Journal Site: Abstract, Full Paper

Premkumar, L., Auerbach, A. (1997)
Stoichiometry of Recombinant N-Methyl-D-Aspartate Receptor Channels Inferred from Single-channel Current Patterns
J. Gen. Physiol. 110: 485-502.